Expanding Bromodomain Targeting into Neglected Parasitic Diseases

Abstract

This Perspective discusses the published data and recent developments in the research area of bromodomains in parasitic protozoa. Further work is needed to evaluate the tractability of this target class in the context of infectious diseases and launch drug discovery campaigns to identify and develop antiparasite drugs that can offer differentiated mechanisms of action.

Keywords: bromodomain; drug discovery; epigenetics; kinetoplastids; plasmodium; targets.