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. 2022 Feb;38(2):379-386.
doi: 10.1007/s00381-021-05339-w. Epub 2021 Oct 6.

Cerebrospinal fluid velocity changes of idiopathic scoliosis: a preliminary study on 3-T PC-MRI and 3D-SPACE-VFAM data

O Algin  1   2   3 , U Koc  4 , N Yalcin  5
Affiliations

Cerebrospinal fluid velocity changes of idiopathic scoliosis: a preliminary study on 3-T PC-MRI and 3D-SPACE-VFAM data

O Algin et al. Childs Nerv Syst. 2022 Feb.

Abstract

Objectives: To the best of our knowledge, there is no study on 3-Tesla (3-T) phase-contrast MRI (PC-MRI) and three-dimensional sampling perfection with application-optimized contrasts using different flip-angle evolutions (3D-SPACE-VFAM) in the evaluation of idiopathic scoliosis. This study aimed to investigate CSF abnormalities in the scoliotic spine using 3-T PC-MRI and 3D-SPACE-VFAM techniques.

Methods: Thirty-four patients and 14 controls were examined with spinal PC-MRI and T2-weighted 3D-SPACE-VFAM techniques. Inter- and intra-reader agreements of flow-void phenomenon on 3D-SPACE-VFAM images, and velocity values on PC-MRI data were also evaluated.

Results: There are statistically significant differences between scoliosis and control groups based on the highest and mean peak velocity values on PC-MRI images (p = 0.005 and p = 0.023, respectively). The main thoracic (MT) group's highest peak CSF velocity values were higher than the control group (p = 0.022). There is a significant difference between the patient and control groups regarding flow-void phenomenon scores on 3D-SPACE-VFAM images (p = 0.036). Inter- and intra-reader agreement values related to PC-MRI velocity measurements were perfect for all PC-MRI readings. Inter- and intra-reader agreement values of the flow-void phenomenon scores were moderate.

Conclusions: Our study has led us to conclude that idiopathic scoliosis is associated with CSF flow disturbances in parallel with the literature. MRI can demonstrate these abnormalities in a non-invasive and radiation-free way.

Keywords: 3-Tesla; 3D-SPACE; CSF; Idiopathic scoliosis; Magnetic resonance imaging; PC-MRI.

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References

    1. Kim H, Kim HS, Moon ES et al (2010) Scoliosis imaging: what radiologists should know. Radiographics 30(7):1823–1842 - DOI
    1. Van Gennip JLM, Boswell CW, Ciruna B (2018) Neuroinflammatory signals drive spinal curve formation in zebrafish models of idiopathic scoliosis. Sci Adv 4(12):eaav1781
    1. Faizah MZ, Ng KL, Te BC et al (2016) Association of Cobb angle progression and neuraxial abnormality on MRI in asymptomatic adolescent idiopathic scoliosis. Med J Malaysia 71(3):122–125 - PubMed
    1. Grimes DT, Boswell CW, Morante NF, Henkelman RM, Burdine RD, Ciruna B (2016) Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature. Science 352(6291):1341–1344 - DOI
    1. Duchaussoy T, Lacoste M, Norberciak L, Decaudain J, Verclytte S, Budzik JF (2019) Preoperative assessment of idiopathic scoliosis in adolescent and young adult with three-dimensional T2-weighted spin-echo MRI. Diagn Interv Imaging 100(6):371–379 - DOI

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