Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Nov 2;17(11):4259-4264.
doi: 10.1080/21645515.2021.1969852. Epub 2021 Oct 6.

Safety of Japanese encephalitis vaccines

Ya-Li Hu  1 , Ping-Ing Lee  2
Affiliations

Safety of Japanese encephalitis vaccines

Ya-Li Hu et al. Hum Vaccin Immunother. .

Abstract

Japanese encephalitis (JE) is an endemic disease dominantly in the Asia-Pacific region with mortality rate varying between 3% and 30%. Long-term neuropsychiatric sequelae developed in 30-50% of the survivors. There is no available antiviral therapy for JE. JE vaccines play a major role in preventing this devastating disease. The incidence of JE declined over years and the age distribution shifted toward adults in countries where JE immunization program exists. Mouse brain-JE vaccine is currently replaced by inactivated Vero cell-derived vaccine and live-attenuated vaccine using SA14-14-2 strain, and live chimeric JE vaccines. These three types of JE vaccines are associated with favorable efficacy and safety profiles. Common adverse reactions include injection site reactions and fever, and severe adverse reactions are rare.

Keywords: Japanese encephalitis; epidemiology; live-attenuated chimeric vaccine; safety; vaccine.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Timeline of the development of four main Japanese encephalitis vaccines.
See this image and copyright information in PMC

References

    1. Mansfield KL, Hernández-Triana LM, Banyard AC, Fooks AR, Johnson N.. Japanese encephalitis virus infection, diagnosis and control in domestic animals. Vet Microbiol. 2017;201:85–92. doi:10.1016/j.vetmic.2017.01.014. - DOI - PubMed
    1. Solomon T. Control of Japanese encephalitis–within our grasp? N Engl J Med. 2006;355:869–71. doi:10.1056/NEJMp058263. - DOI - PubMed
    1. Filgueira FL. Review of emerging Japanese encephalitis virus: new aspects and concepts about entry into the brain and inter-cellular spreading. Pathogens. 2019;8(3):111. doi:10.3390/pathogens8030111. - DOI - PMC - PubMed
    1. Zheng Y, Li M, Wang H, Liang G. Japanese encephalitis and Japanese encephalitis virus in mainland China. Rev Med Virol. 2012;22:301–22. doi:10.1002/rmv.1710. - DOI - PubMed
    1. Dung NM, Turtle L, Chong WK, Mai NT, Thao TT, Thuy TT, Kneen R, Phu NH, Wills B, Farrar J, et al. An evaluation of the usefulness of neuroimaging for the diagnosis of Japanese encephalitis. J Neurol. 2009;256:2052–60. doi:10.1007/s00415-009-5249-5. - DOI - PubMed

MeSH terms

Substances

LinkOut - more resources