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Review
. 2021 Oct 1;30(5):231-243.
doi: 10.1097/RMR.0000000000000273.

Reperfusion Therapies for Children With Arterial Ischemic Stroke

Jeremy J Heit  1   2 , Prakash Muthusami  3 , Ronil V Chandra  4 , Ferdinand Hui  5 , Matias Negrotto  6 , Sarah Lee  7 , Bruce A Wasserman  5 , Todd A Abruzzo  8   9   10
Affiliations
Review

Reperfusion Therapies for Children With Arterial Ischemic Stroke

Jeremy J Heit et al. Top Magn Reson Imaging. .

Abstract

Modern hyperacute reperfusion therapies including intravenous thrombolysis and mechanical thrombectomy have transformed the management of arterial ischemic stroke (AIS) in adults. Multiple randomized clinical trials have demonstrated that these therapies enable remarkable improvements in clinical outcome for properly selected patients with AIS. Because pediatric patients were excluded from predicate clinical trials, there is a conspicuous lack of data to guide selection of therapies and inform age-adjusted and pathology-oriented treatment modifications for children. Specifically, technical guidance concerning treatment eligibility, drug dosing, and device implementation is lacking. This review aims to outline important features that differentiate pediatric AIS from adult AIS and provide practical strategies that will assist the stroke specialist with therapeutic decision making.

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Conflict of interest statement

The authors report no conflicts of interest.

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