Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2022 Mar;39(2):509-516.
doi: 10.1111/phn.12985. Epub 2021 Oct 6.

Meta-analysis of whether influenza vaccination attenuates symptom severity in vaccinated influenza patients

Ye Pan  1 , Lijiang Du  2 , Quan Gan  2 , Wei Ma  2 , Meifen Wang  2 , Zhiying Lu  2 , Yunjiao Luo  2
Affiliations
Meta-Analysis

Meta-analysis of whether influenza vaccination attenuates symptom severity in vaccinated influenza patients

Ye Pan et al. Public Health Nurs. 2022 Mar.

Abstract

Background: Influenza vaccination has been associated with decreased risk of influenza-related infections. However, associations between influenza vaccination and the severity of influenza cases have not been systematically summarized. We conducted a meta-analysis to evaluate whether influenza vaccination could attenuate symptom severity in vaccinated influenza patients.

Methods: A systematic literature search was performed using the PubMed, Web of Science, EMBASE, and Scopus databases. A quantitative synthesis of the data was conducted using a fixed/random effects model in the meta-analysis.

Results: A total of seven studies, involving 6342 vaccinated and 7036 non-vaccinated patients were included. Compared with non-vaccinated, vaccinated patients were significantly less likely to develop a fever (OR = 0.66, 95% CI: 0.43-0.89), be admitted to the ICU (OR = 0.79, 95% CI: 0.64-0.97), suffer mortality (OR = 0.55, 95% CI: 0.34-0.89), stay in the ICU (WMD = -1.37, 95% CI: -2.15 to -0.60) or stay in the hospital (WMD = -0.32, 95% CI: -0.61 to -0.04).

Conclusion: Those benefits that could be highlighted in the communication material to enhance the uptake of influenza vaccination among both the public health nurses and the community as a whole.

Keywords: influenza vaccines; meta-analysis; respiratory system; signs and symptoms.

PubMed Disclaimer

References

REFERENCES

    1. Ades, A. E., Lu, G., & Higgins, J. P. T. (2005). The interpretation of random-effects meta-analysis in decision models. Medical Decision Making, 25(6), 646-654. https://doi.org/10.1177/0272989%D7;05282643
    1. Andrade, C. (2020). Mean difference, standardized mean difference (SMD), and their use in meta-analysis: As simple as it gets. Journal of Clinical Psychiatry, 81(5), https://doi.org/10.4088/JCP.20f13681
    1. Arriola, C., Garg, S., Anderson, E. J., Ryan, P. A., George, A., Zansky, S. M., Bennett, N., Reingold, A., Bargsten, M., Miller, L., Yousey-Hindes, K., Tatham, L., Bohm, S. R., Lynfield, R., Thomas, A., Lindegren, M. L., Schaffner, W., Fry, A. M., & Chaves, S. S. (2017). Influenza vaccination modifies disease severity among community-dwelling adults hospitalized with influenza. Clinical Infectious Diseases, 65(8), 1289-1297. https://doi.org/10.1093/cid/cix468
    1. Arriola, C. S., Anderson, E. J., Baumbach, J., Bennett, N., Bohm, S., Hill, M., Lindegren, M. L., Lung, K., Meek, J., Mermel, E., Miller, L., Monroe, M. L., Morin, C., Oni, O., Reingold, A., Schaffner, W., Thomas, A., Zansky, S. M., Finelli, L., & Chaves, S. S. (2015). Does influenza vaccination modify influenza severity? Data on older adults hospitalized with influenza during the 2012-2013 season in the United States. Journal of Infectious Diseases, 212(8), 1200-1208. https://doi.org/10.1093/infdis/jiv200
    1. Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2010). A basic introduction to fixed-effect and random-effects models for meta-analysis. Research Synthesis Methods, 1(2), 97-111. https://doi.org/10.1002/jrsm.12

Publication types

Substances

LinkOut - more resources