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Comment
. 2021 Oct 5;33(10):1903-1905.
doi: 10.1016/j.cmet.2021.09.005.

Targeting senescent immune cells to rejuvenate the aging skeleton

Ge Zhang  1 , Jin Liu  2
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Comment

Targeting senescent immune cells to rejuvenate the aging skeleton

Ge Zhang et al. Cell Metab. .
Free article

Abstract

Accumulation of senescent cells in the bone marrow leads to age-related bone degeneration. Identifying the key senescent cell types and the factors they release that are responsible for skeletal aging is of keen interest. In a new study by Li et al. (2021), it is shown that immune cells, including neutrophils and macrophages, are critical cell types in this aging process, and that they secrete grancalcin to promote such aging.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Senescent immune cells release grancalcin to promote skeletal aging.
    Li CJ, Xiao Y, Sun YC, He WZ, Liu L, Huang M, He C, Huang M, Chen KX, Hou J, Feng X, Su T, Guo Q, Huang Y, Peng H, Yang M, Liu GH, Luo XH. Li CJ, et al. Cell Metab. 2021 Oct 5;33(10):1957-1973.e6. doi: 10.1016/j.cmet.2021.08.009. Epub 2021 Sep 9. Cell Metab. 2021. PMID: 34614408

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