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Comment
. 2021 Oct 5;33(10):1905-1907.
doi: 10.1016/j.cmet.2021.09.006.

The Gro3p factor: Restoring NAD+/NADH homeostasis to ameliorate mitochondrial disease

Divakar S Mithal  1 , Navdeep S Chandel  2
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The Gro3p factor: Restoring NAD+/NADH homeostasis to ameliorate mitochondrial disease

Divakar S Mithal et al. Cell Metab. .
Free article

Abstract

Leigh syndrome, a mitochondrial disease, can be modeled in mice with a deficiency in mitochondrial complex I that results in a decreased NAD+/NADH ratio. In this issue of Cell Metabolism, Liu et al. (2021) identify glycerol-3-phosphate (Gro3P) biosynthesis as a method for regenerating cytosolic NAD+ to ameliorate pathology in this mitochondrial disease model.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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