Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1986 Aug;83(15):5597-601.
doi: 10.1073/pnas.83.15.5597.

Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids

P S Henthorn, B J Knoll, M Raducha, K N Rothblum, C Slaughter, M Weiss, M A Lafferty, T Fischer, H Harris
Comparative Study

Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids

P S Henthorn et al. Proc Natl Acad Sci U S A. 1986 Aug.

Abstract

Amino-terminal amino acid sequences (42 residues) were determined for the products of the three common alleles at the human placental alkaline phosphatase [orthophosphoric-monoester phosphohydrolase (alkaline optimum), EC 3.1.3.1] gene locus. The sequences differ at position 3, which is proline in types 1 and 2 but is leucine in type 3. cDNA libraries were constructed in phage lambda gt11 and used to isolate clones covering the coding regions of types 1 and 3 cDNAs. Comparison of the deduced amino acid sequences of the types 1 and 3 proteins showed 7 differences out of 513 amino acids, each due to a single base substitution. cDNA sequence comparisons showed three silent substitutions in the coding regions and three base differences in the greater than 1 kilobase pairs of 3' untranslated sequences.

PubMed Disclaimer

References

    1. EMBO J. 1983;2(3):453-62 - PubMed
    1. J Biol Chem. 1986 Mar 5;261(7):3112-5 - PubMed
    1. Ann Hum Genet. 1967 Jan;30(3):219-32 - PubMed
    1. Proc Natl Acad Sci U S A. 1972 Jun;69(6):1408-12 - PubMed
    1. Ann Hum Genet. 1974 Jan;37(3):237-53 - PubMed

Publication types

Associated data