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. 1986 Sep;182(4):564-7.
doi: 10.3181/00379727-182-4-rc2.

Interferon inducing transformed cell surface glycoproteins: purification by Ia antigen affinity chromatography

T K Hughes, E M Smith, J E Blalock

Interferon inducing transformed cell surface glycoproteins: purification by Ia antigen affinity chromatography

T K Hughes et al. Proc Soc Exp Biol Med. 1986 Sep.

Abstract

Ia antigens were previously shown to be B-cell receptors for transformed cell surface glycoproteins (TCSG). Ia antigen recognition of TCSG subsequently initiated interferon production. These findings have been exploited to highly purify TCSG from mouse L (H-2k) cells in one step by Iak antigen Sepharose affinity chromatography. These results point to the highly specific recognition of TCSG by Ia antigens and the B-cells on which they reside. The implications and applications of these studies are discussed.

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