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Review
. 2022 May 1;30(3):221-231.
doi: 10.4062/biomolther.2021.089.

The Role of Adiponectin in the Skin

Jieun Oh  1 , Yeongyeong Lee  1 , Sae-Woong Oh  2 , TianTian Li  1 , Jiwon Shin  1 , See-Hyoung Park  3 , Jongsung Lee  1   2
Affiliations
Review

The Role of Adiponectin in the Skin

Jieun Oh et al. Biomol Ther (Seoul). .

Abstract

Adiponectin (Ad), a 30 kDa molecule, is an anti-diabetic adipokine; although derived from adipose tissue, it performs numerous activities in various other tissues. It binds to its own receptors, namely adiponectin receptor 1(AdipoR1), adiponectin receptor 2 (AdipoR2), and T-cadherin (CDH13). Ad plays several roles, especially as a regulator. It modulates lipid and glucose metabolism and promotes insulin sensitivity. This demonstrates that Ad has a robust correlation with fat metabolism. Furthermore, although Ad is not in direct contact with other tissues, including the skin, it can be delivered to them by diffusion or secretion via the endocrine system. Recently it has been reported that Ad can impact skin cell biology, underscoring its potential as a therapeutic biomarker of skin diseases. In the present review, we have discussed the association between skin cell biology and Ad. To elaborate further, we described the involvement of Ad in the biology of various types of cells in the skin, such as keratinocytes, fibroblasts, melanocytes, and immune cells. Additionally, we postulated that Ad could be employed as a therapeutic target to maintain skin homeostasis.

Keywords: Adaptive immunity; Adiponectin; Fibroblast; Innate immunity; Keratinocyte; Melanocyte.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors have declared no conflicting interests.

Figures

Fig. 1
Fig. 1
Structure of globular adiponectin and adiponectin receptors. gAd, globular adiponectin.
Fig. 2
Fig. 2
Effects of adiponectin on various types of cells in skin.
Fig. 3
Fig. 3
Simple scheme of adiponectin action mechanisms in melanogenesis.
See this image and copyright information in PMC

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