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Review
. 2021 Sep 27:2021:9962860.
doi: 10.1155/2021/9962860. eCollection 2021.

The Role of Oxidative Stress and Antioxidant Balance in Pregnancy

Tarique Hussain  1   2 , Ghulam Murtaza  3 , Elsayed Metwally  4 , Dildar Hussain Kalhoro  5 , Muhammad Saleem Kalhoro  6 , Baban Ali Rahu  3 , Raja Ghazanfar Ali Sahito  7 , Yulong Yin  8 , Huansheng Yang  9 , Muhammad Ismail Chughtai  2 , Bie Tan  1
Affiliations
Review

The Role of Oxidative Stress and Antioxidant Balance in Pregnancy

Tarique Hussain et al. Mediators Inflamm. .

Abstract

It has been widely known that oxidative stress disrupts the balance between reactive oxygen species (ROS) and the antioxidant system in the body. During pregnancy, the physiological generation of ROS is involved in a variety of developmental processes ranging from oocyte maturation to luteolysis and embryo implantation. While abnormal overproduction of ROS disrupts these processes resulting in reproductive failure. In addition, excessive oxidative stress impairs maternal and placental functions and eventually results in fetal loss, IUGR, and gestational diabetes mellitus. Although some oxidative stress is inevitable during pregnancy, a balancing act between oxidant and antioxidant production is necessary at different stages of the pregnancy. The review aims to highlight the importance of maintaining oxidative and antioxidant balance throughout pregnancy. Furthermore, we highlight the role of oxidative stress in pregnancy-related diseases.

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Conflict of interest statement

All authors have no any conflict of interest.

Figures

Figure 1
Figure 1
The Impact of Oxidative Stress on Pregnancy Outcomes.
See this image and copyright information in PMC

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