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. 2021 Oct 4;7(4):00237-2021.
doi: 10.1183/23120541.00237-2021. eCollection 2021 Oct.

Protein levels, air pollution and vitamin D deficiency: links with allergy

Yong Song  1 , E Haydn Walters  2   3 , Michael J Abramson  4 , Gayan Bowatte  2   5   6 , Dinh S Bui  2 , Jennifer Perret  2 , Iain Feather  7 , Luke D Knibbs  8 , Richard Wilson  9 , David S Nichols  9 , Shyamali C Dharmage  2 , Graeme R Zosky  1   3
Affiliations

Protein levels, air pollution and vitamin D deficiency: links with allergy

Yong Song et al. ERJ Open Res. .

Abstract

This study provides novel insights into mechanisms of traffic-related air pollution-induced allergy by down-regulation via complement regulators (CFI, PROS1 and PLG) and its interaction with vitamin D deficiency via the complement inhibitor PLG https://bit.ly/3x0jYOw.

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Conflict of interest statement

Conflict of interest: M.J. Abramson holds investigator-initiated grants for unrelated research from Pfizer and Boehringer Ingelheim. He has undertaken an unrelated consultancy for and received assistance with conference travel from Sanofi. He has also received a speaker's fee from GSK. S.C. Dharmage holds investigator-initiated grants for unrelated research from GSK. The other authors declare that they have no relevant conflicts of interest.

Figures

FIGURE 1
FIGURE 1
a) Heatmap showing expression of the five proteins downregulated in the participants with high NO2 and low vitamin D levels. b) Gene ontology annotation and c) the Kyoto Encyclopedia of Genes and Genomes (KEGG) database was used to identify significantly enriched biological processes and pathways, with the Benjamini p-value shown. The expression of selected proteins were compared between d) low (n=50) and high NO2 (n=24) groups, and e) in the individuals with (n=16) and without (n=54) mixed grass pollen (Kentucky bluegrass, orchard, redtop, timothy, sweet vernal grass and meadow fescue) allergy using general linear models, with adjustment for sex and smoking status. Principal component analysis (PCA) was applied to group the correlated proteins in the complement and coagulation cascades, with generation of two scores: PCA1 (56%) and PCA2 (35%). PLG: plasminogen; CFI: complement factor I; PROS1: protein S (alpha).
See this image and copyright information in PMC

References

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