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. 2022 Mar;67(1):356-361.
doi: 10.1007/s11686-021-00471-8. Epub 2021 Oct 6.

Toxoplasmosis in Treatment-Resistant Obsessive-Compulsive Disorder Patients

Forough Kazemi  1   2 , Mehdi Sayyah  3 , Mehdi Tavalla  2   4 , Reza Arjmand  5   6
Affiliations

Toxoplasmosis in Treatment-Resistant Obsessive-Compulsive Disorder Patients

Forough Kazemi et al. Acta Parasitol. 2022 Mar.

Abstract

Background and objectives: The current study was done to evaluate the relationship between T. gondii and obsessive-compulsive disorder (OCD) as well as prevalence rate of toxoplasmosis in treatment-resistant patients with OCD in comparison with treatment-sensitive patients with OCD.

Methods: A total of 180 subjects were selected, including 90 patients with OCD and 90 control participants. Immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies against T. gondii were measured by the enzyme-linked immunosorbent assay (ELISA) technique. Detection of acute and chronic toxoplasmosis was carried out using the ELISA IgG avidity. In addition, the presence of this parasite in blood was detected using the nested-polymerase chain reaction (PCR) method.

Results: Regarding T. gondii IgG antibodies 42 (46.7%) and 17 (18.9%) cases were detected in the patients and controls, respectively (P = 0.000). Also, 16 (17.8%) and 5 (5.6%) cases were positive for B1 gene in patients and controls, respectively (P = 0.018). The antibodies were found to be related to risk of OCD [OR (95% CI) = 3.71 (1.88-7.30); P < 0.001]. Moreover, out of 90 patients, 35 and 55 cases were resistant and sensitive to treatment, respectively, so that 24 (68.6%) out of 35 and 18 (32.7%) out of 55 were positive for the antibodies (P = 0.01) as well as 11 (31.4%) out of 35 and 5 (9.1%) out of 55 were positive for B1 gene (P = 0.010). The antibodies were also associated with risk of resistance to treatment in patients with OCD [OR (95% CI) = 3.81 (1.42-10.17); P = 0.008].

Conclusion: Our findings showed that toxoplasmosis was more frequent in patients with OCD than the control group. In addition, prevalence rate of toxoplasmosis in treatment-resistant patients with OCD was significantly more than that in treatment-sensitive patients with OCD.

Keywords: Obsessive–compulsive disorder; Toxoplasma Gondii; Toxoplasmosis; Treatment resistance.

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References

    1. Chegeni TN, Sarvi S, Amouei A, Moosazadeh M, Hosseininejad Z, Aghayan SA et al (2019) Relationship between toxoplasmosis and obsessive compulsive disorder: a systematic review and meta-analysis. PLoS Neglected Tropical Dis 13(4):e0007306. https://doi.org/10.1371/journal.pntd.0007306 - DOI
    1. Alvarado-Esquivel C, Sanchez-Anguiano LF, Hernandez-Tinoco J, Berumen-Segovia LO, Torres-Prieto YE, Estrada-Martinez S, et al (2016). Toxoplasma gondii infection and mixed anxiety and depressive disorder: a case-control seroprevalence study in Durango, Mexico. J Clin Med Res 8(7):519. https://doi.org/10.14740/jocmr2576w .
    1. de Barros JLVM, Barbosa IG, Salem H, Rocha NP, Kummer A, Okusaga OO et al (2017) Is there any association between Toxoplasma gondii infection and bipolar disorder? A systematic review and meta-analysis. J Affective Dis 209:59–65. https://doi.org/10.1016/j.jad.2016.11.016 - DOI
    1. Cetinkaya Z, Yazar S, Gecici O, Namli MN (2007) Anti-Toxoplasma gondii antibodies in patients with schizophrenia—preliminary findings in a Turkish sample. Schizophrenia Bull 33(3):789–791. https://doi.org/10.1093/schbul/sbm021 - DOI
    1. Ene L, Marcotte T, Umlauf A, Grancea C, Temereanca A, Bharti A et al (2016) Latent toxoplasmosis is associated with neurocognitive impairment in young adults with and without chronic HIV infection. J Neuroimmunol 299:1–7. https://doi.org/10.1016/j.jneuroim.2016.08.003 - DOI - PMC

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