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Review
. 2021 Nov;35(11):e24038.
doi: 10.1002/jcla.24038. Epub 2021 Oct 7.

CircRNAs: a family number of miRNA regulatory transcriptome in laryngeal carcinoma

Limin Miao  1   2 , Guanying Feng  2   3 , Hua Yuan  2   3
Affiliations
Review

CircRNAs: a family number of miRNA regulatory transcriptome in laryngeal carcinoma

Limin Miao et al. J Clin Lab Anal. 2021 Nov.

Abstract

Laryngeal carcinoma (LC) is a common head and neck cancer, which is the result of mutational changes due to gene dysregulation and etiological factors such as tobacco and smoking. A large number of patients received a poor prognosis due to diagnosis at an advanced stage. This highlights the need for definitive, early, and efficient diagnoses. With rapid development of high-throughput sequencing, circular RNA (circRNA) has been reported to play a pivotal role in cancer. CircRNA functions as a microRNA (miRNA) sponge in the regulation of mRNA expression, forming circRNA-miRNA regulatory axis. In this review, we described the axis in LC. The result indicated that CDR1as, hsa_circ_0042823, hsa_circ_0023028, circPARD3, hsa_circ_103862, hsa_circ_0000218, circMYLK, circCORO1C, hsa_circ_100290, circ-CCND1, hsa_circ_0057481, circFLAN, and circRASSF2 expressed higher in LC, whereas, hsa_circ_0036722 and hsa_circ_0042666 expressed lower. The circRNAs regulated the target genes by sponging miRNAs and contributed to the pathogenesis of LC.

Keywords: circRNA; circRNA-miRNA axis; laryngeal carcinoma; miRNA sponge; regulation.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

FIGURE 1
FIGURE 1
The biogenesis of circRNAs. Base repairing inverted repeat elements (such as Alu elements) bring a downstream splice‐donor site into close proximity with an upstream splice‐acceptor site, and this association may lead to back‐splicing. circRNAs can also be generated from splicing intermediates known as lariat precursors that are created by an exon‐skipping event during linear splicing or from intronic lariat precursors that escape from the debranching step of canonical linear splicing. miRNA sponged by circRNA in the cytoplasm
See this image and copyright information in PMC

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