Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan;48(1):121-123.
doi: 10.1007/s00134-021-06538-4. Epub 2021 Oct 7.

Critical care ultrasound goal-directed versus early goal-directed therapy in septic shock

Kun Yu #  1 , Shucheng Zhang #  1   2 , Ni Chen #  1 , Miao Chen  3 , Wei Zhang  4   5 ; CCUGDT Study Group
Collaborators, Affiliations

Critical care ultrasound goal-directed versus early goal-directed therapy in septic shock

Kun Yu et al. Intensive Care Med. 2022 Jan.
No abstract available

PubMed Disclaimer

Conflict of interest statement

All authors declare that there are no conflicts of interest involved in the article.

Figures

Fig. 1
Fig. 1
Study flow chart. ICU intensive care unit, Sepsis-3 Third International Consensus Definitions for Sepsis and Septic Shock, CKD chronic kidney disease, EGDT early goal-directed therapy, CCUGDT critical care ultrasound goal-directed therapy, CVP central venous pressure, MAP mean arterial pressure, SCVO2 central venous oxygen saturation, LVEF left ventricular ejection fraction, TAPSE tricuspid annular plane systolic excursion, SV stroke volume, SVC superior vena cava, NE norepinephrine, HCT hematocrit. *To avoid excessive fluid infusion during fluid resuscitation we adopted a descending fluid infusion strategy: the first dose was given at 15 mL/kg body weight the second dose was given at 10 mL/kg body weight and the third dose was given at 5 mL/kg body weight. Whether to give the next fluid infusion was dependent upon on the critical care ultrasound evaluation result after the last fluid infusion.
See this image and copyright information in PMC

Comment in

  • Goal-directed therapy in sepsis strikes back.
    Skurzak S, Gallo M, Lavezzo B, Iannandrea S, Balagna R. Skurzak S, et al. Intensive Care Med. 2022 Apr;48(4):502-503. doi: 10.1007/s00134-021-06569-x. Epub 2021 Nov 8. Intensive Care Med. 2022. PMID: 34748041 No abstract available.
  • Goal-directed therapy in sepsis strikes back. Author's reply.
    Zhang S, Li B, Yi S, He Z, Zhang W. Zhang S, et al. Intensive Care Med. 2022 Apr;48(4):504-506. doi: 10.1007/s00134-022-06633-0. Epub 2022 Feb 14. Intensive Care Med. 2022. PMID: 35165748 No abstract available.

References

    1. Vieillard-Baron A, Millington SJ, Sanfilippo F, Chew M, Diaz-Gomez J, McLean A, Pinsky MR, Pulido J, Mayo P, Fletcher N. A decade of progress in critical care echocardiography: a narrative review. Intensive Care Med. 2019;45:770–788. doi: 10.1007/s00134-019-05604-2. - DOI - PubMed
    1. Schnittke N, Schmidt J, Barvalia U, Emmerich K, Kory P, Damewood S. Assessment of dynamic changes in cardiac function during resuscitation of patients with suspected septic shock: a prospective, observational, cohort study. Am J Emerg Med. 2020;38:2653–2657. doi: 10.1016/j.ajem.2020.08.058. - DOI - PubMed
    1. Feng M, McSparron JI, Kien DT, Stone DJ, Roberts DH, Schwartzstein RM, Vieillard-Baron A, Celi LA. Transthoracic echocardiography and mortality in sepsis: analysis of the MIMIC-III database. Intensive Care Med. 2018;44:884–892. doi: 10.1007/s00134-018-5208-7. - DOI - PubMed
    1. Lanspa MJ, Burk RE, Wilson EL, Hirshberg EL, Grissom CK, Brown SM. Echocardiogram-guided resuscitation versus early goal-directed therapy in the treatment of septic shock: a randomized, controlled, feasibility trial. J Intensive Care. 2018;6:50. doi: 10.1186/s40560-018-0319-3. - DOI - PMC - PubMed
    1. Zhang W (2021) Critical care ultrasound goal-directed versus early goal-directed therapy in septic shock: a randomized controlled study. 10.1186/s40635-021-00413-8 - PMC - PubMed

LinkOut - more resources