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Review
. 2021 Dec;21(12):4015-4031.
doi: 10.1002/tcr.202100231. Epub 2021 Oct 7.

Construction of Carbon-Fluorine Bonds via Copper-Catalyzed/-Mediated Fluorination Reactions

Tao Dong  1 , Gavin Chit Tsui  1
Affiliations
Review

Construction of Carbon-Fluorine Bonds via Copper-Catalyzed/-Mediated Fluorination Reactions

Tao Dong et al. Chem Rec. 2021 Dec.

Abstract

The construction of carbon-fluorine bonds is an important yet challenging task in organic synthesis. Transition metal-catalyzed/-mediated C-F bond forming processes have recently emerged as a viable strategy and provided access to value-added monofluorinated compounds. A dramatic increase in fluorination methods using inexpensive and earth-abundant copper can be seen in the past decade surpassing those using palladium and silver. This review discusses the recent development of Cu-catalyzed/-mediated formation of C(sp2 )-F and C(sp3 )-F bonds.

Keywords: C−F bond; copper; fluorination; organofluorine; selectivity.

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References

    1. None
    1. H. Mei, J. Han, S. Fustero, M. Medio-Simon, D. M. Sedgwick, C. Santi, R. Ruzziconi, V. A. Soloshonok, Chem. Eur. J. 2019, 25, 11797-11819;
    1. N. A. Meanwell, J. Med. Chem. 2018, 61, 5822-5880;
    1. D. O'Hagan, J. Fluorine Chem. 2010, 131, 1071-1081;
    1. T. Fujiwara, D. O'Hagan, J. Fluorine Chem. 2014, 167, 16-29;

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