Gut bacteria enable prostate cancer growth

John A McCulloch^{1

2}, Giorgio Trinchieri³

Affiliations

¹ Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
² Genetics and Microbiome Core, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
³ Cancer Immunobiology Section, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

Comment

John A McCulloch et al. Science. 2021.

. 2021 Oct 8;374(6564):154-155.

doi: 10.1126/science.abl7070. Epub 2021 Oct 7.

John A McCulloch^{1

2}, Giorgio Trinchieri³

¹ Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
² Genetics and Microbiome Core, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
³ Cancer Immunobiology Section, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

Abstract

Testosterone-synthetizing gut bacteria drive resistance to therapy.

Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis.
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