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. 2021 Oct 7;16(10):e0257915.
doi: 10.1371/journal.pone.0257915. eCollection 2021.

Genotype distribution of cervical HPV among Caribbean women in a population-based study in Martinique: The DEPIPAPUFR study

Fatiha Najioullah  1 , Marie-José Dorival  2 , Clarisse Joachim  3 , Christiane Dispagne  4 , Jonathan Macni  3 , Sylvie Abel  5 , Caroline Sulpicy  2 , Huguette Charpentier-Baltide  6 , Danièle Sainte-Rose  7 , Béatrice Salomon-Frechou  8 , Moustapha Dieye  9 , Jacqueline Véronique-Baudin  3 , Maurice Pré  10 , Maurice Marquet  11 , Gaëlle Wan-Ajouhu  7 , Eustase Janky  12 , Didier Riethmuller  13 , Raymond Cesaire  1 ; DEPIPAPUFR study group
Affiliations

Genotype distribution of cervical HPV among Caribbean women in a population-based study in Martinique: The DEPIPAPUFR study

Fatiha Najioullah et al. PLoS One. .

Abstract

The Caribbean ranks seventh among the world regions most affected by cervical cancer. HPV-prevalence and genotype distributions also differ from regions. Knowledge of HPV genotype profiles is important for patients care and HPV vaccination implementation. The objective of this study was to describe HPV genotype distribution and risk factors in a population-based cohort of women in Martinique. In this study, 1312 women were included and underwent cervical cancer screening with successful sample collection between 2009 and 2014. Sociodemographic and clinical variables were recorded. Cytological examination of cervical vaginal smear was performed and classified(Bethesda). Detection of HPV DNA was performed with the PapilloCheck© Kit from Greiner Bio-one. Genotypes were analyzed for18 high-risk HPV (hrHPV) and 6low-risk HPV(lrHPV) types. A total of 1075 women were included with a mean age of 49.1±10.5 years. HPV prevalence was 27.6% (297/1075) with 19.4% (209/1075) women with only hrHPV, 5.3% (57/1075) with only lrHPV. Multiple infections (hrHPV/lrHPV) were detected in 31/240 cases of hrHPV (12.9%). A total of 353 hrHPV genotypes were analyzed; the most common HPV types were HPV51 (11.0%), HPV68 (10.8%), HPV53 (9.1%) and HPV 52 (7.1%). HPV16 and HPV18 represented respectively 4.8% and 4.0% of hrHPV genotypes. Abnormal cytology was observed in 34 cases (3.2%), with 14 ASCUS (1.3%), 10 LSIL (0.9%), 5 HSIL (0.5%), 3 ASC-H (0.3%) and 2 AGC (0.2%). Fifteen (44.1%) were hrHPV and 4 (14.7%) lrHPV; 7 cases of hrPHV were in the age-group 25-34 years. Among 1041cases of normal cytology, 225 had positive hrHPV detection (21.6%). This is the first population-based study of HPV profiles in our country, and we found a high prevalence of hrHPV. The most common genotypes were HPV51, 68, 53. These results could serve for cancer vaccination strategies and HPV surveillance in Martinique.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flowchart of the study population and number of genotypes identified.
Fig 2
Fig 2. HPV genotypes in the study population in order of frequency.
N = 449 cases of HPV genotypes—(hrHPV in black; lrHPV in grey).
Fig 3
Fig 3. Distribution of hrHPV genotypes by age group, n = 353 women.
See this image and copyright information in PMC

References

    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, et al.. (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68: 394–424. doi: 10.3322/caac.21492 - DOI - PubMed
    1. (2019) Hamers FF, Jezeweski-Serra D. Couverture du dépistage du cancer du col de l’utérus en France, 2012–2017. Bull Epidémiol Hebd. 2019;(22–23):417–23.
    1. French epidemiological center on medical causes of death—French National Institute of Health and Medical Reseearch. https://www.cepidc.inserm.fr/. Accessed 18 Apr 2018.
    1. Joachim-Contaret C, Véronique-Baudin J, Macni J, Ulric-Gervaise S, Cariou M, Billot-Grasset A, et al.. Estimations régionales et départementales d’incidence et de mortalité par cancers en France, 2007–2016. Martinique. Saint-Maurice: Santé publique France, 2019. 106. doi: 10.1186/s12939-019-1087-y - DOI
    1. Wilbur DC, Nayar R (2015) Bethesda 2014: improving on a paradigm shift. Cytopathology 26: 339–342. doi: 10.1111/cyt.12300 - DOI - PubMed

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