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. 2022 Mar;76(3):747-749.
doi: 10.1016/j.jhep.2021.09.031. Epub 2021 Oct 5.

Immune-mediated hepatitis with the Moderna vaccine, no longer a coincidence but confirmed

Affiliations

Immune-mediated hepatitis with the Moderna vaccine, no longer a coincidence but confirmed

Gloria Shwe Zin Tun et al. J Hepatol. 2022 Mar.
No abstract available

Keywords: Immune-mediated liver damage; autoimmune hepatitis; covid-19; drug induced liver injury.

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Conflict of interest statement

Conflict of interest The authors declare no conflicts of interest that pertain to this work. Please refer to the accompanying ICMJE disclosure forms for further details.

Figures

Fig. 1
Fig. 1
Histological findings and biochemical findings. H&E-stained section of liver biopsy indicates acute hepatitis. (A) The parenchymal hepatocytes are arranged into rosette forms (marked with arrows) with cholestasis. (B) BN from hepatocyte loss, some by apoptosis (arrow). (C) Diagram showing trend of bilirubin and ALT following Moderna vaccine dose 1 and 2 with response to prednisolone. ALT, alanine aminotransferase; BN, bridging necrosis. (This figure appears in color on the web.)

References

    1. Bril F., Al Diffalha S., Dean M., Fettig D.M., et al. Autoimmune hepatitis developing after coronavirus disease 2019 (COVID-19) vaccine: causality or casualty? J Hepatol. 2021;75(1):222–224. - PMC - PubMed
    1. Rocco A., Sgamato C., Compare D., Nardone G., et al. Autoimmune hepatitis following SARS-CoV-2 vaccine: may not be a casualty. J Hepatol. 2021;75(3):728–729. - PMC - PubMed
    1. Londono M.C., Gratacos-Gines J., Saez-Penataro J. Another case of autoimmune hepatitis after SARS-CoV-2 vaccination. Still casualty? J Hepatol. 2021 doi: 10.1016/j.jhep.2021.06.004. - DOI - PMC - PubMed
    1. Ghielmetti M., Schaufelberger H.D., Mieli-Vergani G., Cerny A., et al. Acute autoimmune-like hepatitis with atypical anti-mitochondrial antibody after mRNA COVID-19 vaccination: a novel clinical entity? J Autoimmun. 2021;123:102706. - PMC - PubMed
    1. McShane C., Kiat C., Rigby J., Crosbie O., et al. The mRNA COVID-19 vaccine - a rare trigger of Autoimmune Hepatitis? J Hepatol. 2021 S0168-8278(21)01896-1. - PMC - PubMed

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