Forecast of ameliorating effect of dietary flavonol consumption in white tea with or without aerobic training on type 2 diabetes (T2D) in females

Abstract

Background and aims: Diabetes Mellitus (D.M.) is a chronic metabolic disease characterized by hyperglycemia due to insufficient or inefficient insulin secretory response that has become a widespread epidemic primarily due to the increasing prevalence and incidence of type 2 diabetes. Phytochemicals such as flavonoids and regular physical activity have recently attracted attention to developing new anti-diabetic drugs or alternative therapy to control diabetes. The aim of this study was to compare effects of dietary Flavonol consumption in white tea, with or without aerobic training, among patients with type 2 diabetes mellitus as a randomized trial.

Methods: 49 women with T2D were randomly assigned into groups including control, white tea, aerobic training, and aerobic training + white tea. The interventions were carried out for six months. Weight, Body Mass Index (BMI), body Fat, peak oxygen consumption (VO2_Max), and Blood Pressure were evaluated at both the first and last days of the research period. Blood samples were withdrawn on the same days via venipuncture to test blood glucose, insulin, low-density lipoprotein (LDL), high-density lipoprotein (HDL), cholesterol, and triglycerides (T.G.).

Results: Characteristics analysis showed significant improvements in treated groups. In addition, glucose, insulin, LDL, Cholesterol, and T.G. were significantly reduced while HDL was remarkably increased in treated groups compared to pre-experiment values or the diabetic control group.

Conclusion: Collectively, white tea combined with aerobic training favorably affects glycemic parameters, lipid profile, blood pressure, and VO2_Max in six months in women with T2D. Registered under Clinical Trials.gov Identifier no. NCT00123456.

Keywords: Flavonoids; Insulin; Metabolic disorders; Physical activity; Phytochemicals.