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Multicenter Study
. 2021 Oct:45:433-441.
doi: 10.1016/j.clnesp.2021.07.004. Epub 2021 Jul 28.

Characteristics of adult patients with chronic intestinal failure due to short bowel syndrome: An international multicenter survey

Loris Pironi  1 , Ezra Steiger  2 , Francisca Joly  3 , Palle B Jeppesen  4 , Geert Wanten  5 , Anna S Sasdelli  6 , Cecile Chambrier  7 , Umberto Aimasso  8 , Manpreet S Mundi  9 , Kinga Szczepanek  10 , Amelia Jukes  11 , Miriam Theilla  12 , Marek Kunecki  13 , Joanne Daniels  14 , Mireille Serlie  15 , Florian Poullenot  16 , Sheldon C Cooper  17 , Henrik H Rasmussen  18 , Charlene Compher  19 , David Seguy  20 , Adriana Crivelli  21 , Lidia Santarpia  22 , Francesco W Guglielmi  23 , Nada Rotovnik Kozjek  24 , Stéphane M Schneider  25 , Lars Ellegard  26 , Ronan Thibault  27 , Przemysław Matras  28 , Konrad Matysiak  29 , Andrè Van Gossum  30 , Alastair Forbes  31 , Nicola Wyer  32 , Marina Taus  33 , Nuria M Virgili  34 , Margie O'Callaghan  35 , Brooke Chapman  36 , Emma Osland  37 , Cristina Cuerda  38 , Gábor Udvarhelyi  39 , Lynn Jones  40 , Andre D Won Lee  41 , Luisa Masconale  42 , Paolo Orlandoni  43 , Corrado Spaggiari  44 , Marta Bueno Díez  45 , Maryana Doitchinova-Simeonova  46 , Aurora E Serralde-Zúñiga  47 , Gabriel Olveira  48 , Zeljko Krznaric  49 , Laszlo Czako  50 , Gintautas Kekstas  51 , Alejandro Sanz-Paris  52 , Mª Estrella Petrina Jáuregui  53 , Ana Zugasti Murillo  54 , Eszter Schafer  55 , Jann Arends  56 , José P Suárez-Llanos  57 , Nader N Youssef  58 , Giorgia Brillanti  59 , Elena Nardi  60 , Simon Lal  61 ; Home Artificial Nutrition and Chronic Intestinal Failure Special Interest Group of ESPEN; European Society for Clinical Nutrition and Metabolism
Collaborators, Affiliations
Free article
Multicenter Study

Characteristics of adult patients with chronic intestinal failure due to short bowel syndrome: An international multicenter survey

Loris Pironi et al. Clin Nutr ESPEN. 2021 Oct.
Free article

Abstract

Background and aims: The case-mix of patients with intestinal failure due to short bowel syndrome (SBS-IF) can differ among centres and may also be affected by the timeframe of data collection. Therefore, the ESPEN international multicenter cross-sectional survey was analyzed to compare the characteristics of SBS-IF cohorts collected within the same timeframe in different countries.

Methods: The study included 1880 adult SBS-IF patients collected in 2015 by 65 centres from 22 countries. The demographic, nutritional, SBS type (end jejunostomy, SBS-J; jejuno-colic anastomosis, SBS-JC; jejunoileal anastomosis with an intact colon and ileocecal valve, SBS-JIC), underlying disease and intravenous supplementation (IVS) characteristics were analyzed. IVS was classified as fluid and electrolyte alone (FE) or parenteral nutrition admixture (PN). The mean daily IVS volume, calculated on a weekly basis, was categorized as <1, 1-2, 2-3 and >3 L/day.

Results: In the entire group: 60.7% were females and SBS-J comprised 60% of cases, while mesenteric ischaemia (MI) and Crohn' disease (CD) were the main underlying diseases. IVS dependency was longer than 3 years in around 50% of cases; IVS was infused ≥5 days/week in 75% and FE in 10% of cases. Within the SBS-IF cohort: CD was twice and thrice more frequent in SBS-J than SBS-JC and SBS-JIC, respectively, while MI was more frequent in SBS-JC and SBS-JIC. Within countries: SBS-J represented 75% or more of patients in UK and Denmark and 50-60% in the other countries, except Poland where SBS-JC prevailed. CD was the main underlying disease in UK, USA, Denmark and The Netherlands, while MI prevailed in France, Italy and Poland.

Conclusions: SBS-IF type is primarily determined by the underlying disease, with significant variation between countries. These novel data will be useful for planning and managing both clinical activity and research studies on SBS.

Keywords: Epidemiology; Home parenteral nutrition; Intestinal failure; Intravenous supplementation; Short bowel syndrome.

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Conflict of interest statement

Declaration of competing interest None declared.

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