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Review
. 2021 Sep 21:8:739932.
doi: 10.3389/fcvm.2021.739932. eCollection 2021.

Marine Natural Products and Coronary Artery Disease

Bo Liang  1 , Xin-Yi Cai  1 , Ning Gu  2
Affiliations
Review

Marine Natural Products and Coronary Artery Disease

Bo Liang et al. Front Cardiovasc Med. .

Abstract

Coronary artery disease is the major cause of mortality worldwide, especially in low- and middle-income earners. To not only reduce angina symptoms and exercise-induced ischemia but also prevent cardiovascular events, pharmacological intervention strategies, including antiplatelet drugs, anticoagulant drugs, statins, and other lipid-lowering drugs, and renin-angiotensin-aldosterone system blockers, are conducted. However, the existing drugs for coronary artery disease are incomprehensive and have some adverse reactions. Thus, it is necessary to look for new drug research and development. Marine natural products have been considered a valuable source for drug discovery because of their chemical diversity and biological activities. The experiments and investigations indicated that several marine natural products, such as organic small molecules, polysaccharides, proteins, and bioactive peptides, and lipids were effective for treating coronary artery disease. Here, we particularly discussed the functions and mechanisms of active substances in coronary artery disease, including antiplatelet, anticoagulant, lipid-lowering, anti-inflammatory, and antioxidant activities.

Keywords: cardiovascular disease; coronary artery disease; marine; marine natural products; review.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Marine natural products and coronary artery disease.
See this image and copyright information in PMC

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