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Review
. 2021 Sep 21:8:745906.
doi: 10.3389/fcvm.2021.745906. eCollection 2021.

Emerging and Established Histological Techniques for the Analysis of Thrombosis in COVID-19 Lungs

Addie B Spier  1 , Colin E Evans  2   3
Affiliations
Review

Emerging and Established Histological Techniques for the Analysis of Thrombosis in COVID-19 Lungs

Addie B Spier et al. Front Cardiovasc Med. .

Abstract

Coronavirus disease 2019 (COVID-19) is the potentially lethal disease that is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with COVID-19 have an increased risk of thrombosis, but the role of thrombosis in the pathogenesis and progression of severe COVID-19 remains unclear. A better understanding of the contribution of thrombosis to the development and progression of COVID-19 could lead to the development of novel COVID-19 treatments. For this reason, established and emerging histological techniques have recently been used to analyze COVID-19 lungs quantitatively and visually and in two and three dimensions. The gold standard and novel state-of the-art histological techniques that have been used to assess thrombosis in COVID-19 lungs are described in this Mini Review.

Keywords: COVID - 19; histology; lung; pulmonary; thrombosis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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  • Editorial: Highlights in Thrombosis: 2021.
    Evans CE. Evans CE. Front Cardiovasc Med. 2022 Feb 24;9:863030. doi: 10.3389/fcvm.2022.863030. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 35282334 Free PMC article. No abstract available.

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