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Comment
. 2021 Sep 23;2(9):100403.
doi: 10.1016/j.xcrm.2021.100403. eCollection 2021 Sep 21.

Fecal microbiota transplantation and fiber supplementation, better together?

Nordin M J Hanssen  1 , Max Nieuwdorp  1
Affiliations
Comment

Fecal microbiota transplantation and fiber supplementation, better together?

Nordin M J Hanssen et al. Cell Rep Med. .

Abstract

Fecal microbiota transplantation (FMT) is emerging as a tool to study the microbiome and as a potential treatment for several non-infectious diseases. Recently, Mocanu et al. showed that supplementing low fermentable fiber after FMT may improve insulin sensitivity in severely obese individuals.1.

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Conflict of interest statement

M.N. is a founder, holds stock in, and is a member of the Scientific Advisory Board of Caelus Health, the Netherlands. M.N. is on the Scientific Advisory Board of Kaleido Biosciences, USA. N.M.J.H. has received an honorarium from Boehringer Ingelheim. However, none of these conflicts of interest are relevant to this publication.

Figures

Figure 1
Figure 1
Main findings of Mocanu and colleagues In a 2 × 2 factorial design, the authors compared high and low fermentable fiber with and without prior fecal microbial transplantation (FMT) from a lean donor. They reported that 6 weeks after low fermentable fiber supplementation after oral FMT, the homeostatic model assessment (HOMA2-IR), as a marker of insulin resistance, significantly improved. They also reported improved engraftment of the microbiota and incretin production in the group that received low fermentable fiber after donor FMT.
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References

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