Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Sep 1;164(3):938-43.
doi: 10.1084/jem.164.3.938.

HLA-DO polymorphism associated with resistance to type I diabetes detected with monoclonal antibodies, isoelectric point differences, and restriction fragment length polymorphism

G M Schreuder, M G Tilanus, R E Bontrop, G J Bruining, M J Giphart, J J van Rood, R R de Vries

HLA-DO polymorphism associated with resistance to type I diabetes detected with monoclonal antibodies, isoelectric point differences, and restriction fragment length polymorphism

G M Schreuder et al. J Exp Med. .

Abstract

A new HLA-DQ-related genetic system with two alleles, 2B3 and TA10, defined serologically by MAbs and alloantisera, showed an almost perfect correlation with charge differences on DQ beta molecules, as well as with two polymorphic DNA fragments hybridizing with a DQ beta probe and various restriction enzymes on a panel of 14 DR4+ homozygous typing cells. It was therefore concluded that the serologically defined alleles 2B3 and TA10 are coded by the DQ beta gene and situated on the HLA-DQ beta chain. This 2B3/TA10 polymorphism is independent of HLA-D and segregates with HLA in families. The TA10 allele appears to be a new marker for resistance to type I diabetes, which is independent from the known resistance marker DR2, whereas no association was observed between this DQ beta polymorphism and rheumatoid arthritis.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1985 Dec;82(23):8139-43 - PubMed
    1. Immunogenetics. 1986;23(5):333-40 - PubMed
    1. Hum Immunol. 1986 Jun;16(2):127-36 - PubMed
    1. Nature. 1976 Aug 26;262(5571):795-7 - PubMed
    1. J Exp Med. 1982 Aug 1;156(2):550-66 - PubMed

Publication types

MeSH terms