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. 2021 Oct 7;28(10):1675-1677.
doi: 10.1016/j.stem.2021.09.010.

The eyeball's connected to the brain ball

Rajesh C Rao  1 , Jeffrey H Stern  2 , Sally Temple  2
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The eyeball's connected to the brain ball

Rajesh C Rao et al. Cell Stem Cell. .
Free article

Abstract

How does the human eye develop in concert with the brain to create a functioning visual system? In this issue of Cell Stem Cell, Gabriel et al. (2021) report the development of eye-like structures from forebrain organoids with light sensitivity, signal processing, and connectivity, which moves us toward answering this complex question.

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  • Human brain organoids assemble functionally integrated bilateral optic vesicles.
    Gabriel E, Albanna W, Pasquini G, Ramani A, Josipovic N, Mariappan A, Schinzel F, Karch CM, Bao G, Gottardo M, Suren AA, Hescheler J, Nagel-Wolfrum K, Persico V, Rizzoli SO, Altmüller J, Riparbelli MG, Callaini G, Goureau O, Papantonis A, Busskamp V, Schneider T, Gopalakrishnan J. Gabriel E, et al. Cell Stem Cell. 2021 Oct 7;28(10):1740-1757.e8. doi: 10.1016/j.stem.2021.07.010. Epub 2021 Aug 17. Cell Stem Cell. 2021. PMID: 34407456

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