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Meta-Analysis
. 2021 Oct 8;10(1):266.
doi: 10.1186/s13643-021-01820-4.

A characterization of cortisol level and adrenal reservation in human cardiopulmonary arrest: systematic review and meta-analysis

Adeleh Sahebnasagh  1 , Paria Soltani Nejad  2 , Amin Salehi-Abargouei  3   4 , Mohammad Hossein Dehghani  5 , Fatemeh Saghafi  6
Affiliations
Meta-Analysis

A characterization of cortisol level and adrenal reservation in human cardiopulmonary arrest: systematic review and meta-analysis

Adeleh Sahebnasagh et al. Syst Rev. .

Abstract

Background: Cardiopulmonary arrest (CPA) is an urgency, which is associated with high mortality. This systematic review evaluated the relationship between baseline cortisol level and the outcome of resuscitated CPA patients.

Methods: We searched the following databases: PubMed, Scopus, ISI Web of Science, and Google Scholar. Relevant observational and controlled trials were explored from inception by April 2020. The quality of the articles was assessed using the Newcastle-Ottawa Scale (NOS).

Results: Finally, five cohort studies (n = 201 participants in total) were eligible for including in the meta-analysis. The results of this meta-analysis showed that although the baseline serum cortisol levels were higher in survivors of cardiac arrest compared with non-survivors, the differences between groups do not reach a significance level (Hedges' g = 0.371, 95% CI, -0.727, 1.469, P value = 0.508). Between-study heterogeneity was statistically significant (Cochrane Q test: P value < 0.001, I2 = 89.323).

Conclusions: The result of the present meta-analysis was suggestive of a higher baseline serum cortisol levels in survivors of CPA. Future randomized controlled studies with a large sample size will determine the exact relationship between adrenal reservation and the eventual outcome of patients with CPA.

Systematic review registration: PROSPERO CRD42018085468.

Keywords: Adrenal reservation; Cardiac arrest; Cortisol level; Glucocorticoids; Systematic review.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
PRISMA flow diagram
Fig. 2
Fig. 2
Forest plot of eligible cohort studies which were included in the meta-analysis
See this image and copyright information in PMC

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