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Comment
. 2021 Oct 8;6(1):364.
doi: 10.1038/s41392-021-00772-4.

Keep quiet-how stress regulates hair follicle stem cells

Sven R Quist  1   2 , Jennifer Quist  3
Affiliations
Comment

Keep quiet-how stress regulates hair follicle stem cells

Sven R Quist et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Regulation of hair follicle stem cell activity under normal condition and during enhanced corticosterone/stress. HFSC quiescence is regulated by the bulge niche environment. In early telogen, HFCSs remain quiescent through BMP6 and fibroblast growth factor 18, which are secreted from keratin 6+ cells of the inner bulge and BMP4 from DP cells, BMP2 and BMP4 from surrounding fibroblasts and adipocytes and oncostatin M from TREM2+ macrophages. In late telogen, Gas6, BMP inhibitors and TGF-β-2, FGF 7 and 10 activate Wnt signalling, leading to early anagen. High levels of corticosterone/stress suppress Gas6 and prevent the transition from late telogen to anagen prolonging late telogen
See this image and copyright information in PMC

Comment on

  • Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence.
    Choi S, Zhang B, Ma S, Gonzalez-Celeiro M, Stein D, Jin X, Kim ST, Kang YL, Besnard A, Rezza A, Grisanti L, Buenrostro JD, Rendl M, Nahrendorf M, Sahay A, Hsu YC. Choi S, et al. Nature. 2021 Apr;592(7854):428-432. doi: 10.1038/s41586-021-03417-2. Epub 2021 Mar 31. Nature. 2021. PMID: 33790465 Free PMC article.

References

    1. Choi S, et al. Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence. Nature. 2021;592:428–432. doi: 10.1038/s41586-021-03417-2. - DOI - PMC - PubMed
    1. Lee SA, Li KN, Tumbar T. Stem cell-intrinsic mechanisms regulating adult hair follicle homeostasis. Exp. Dermatol. 2021;30:430–447. doi: 10.1111/exd.14251. - DOI - PMC - PubMed
    1. Daszczuk P, et al. An intrinsic oscillation of gene networks inside hair follicle stem cells: an additional layer that can modulate hair stem cell activities. Front Cell Dev. Biol. 2020;8:595178. doi: 10.3389/fcell.2020.595178. - DOI - PMC - PubMed
    1. Wang ECE, Dai Z, Ferrante AW, Drake CG, Christiano AM. A subset of TREM2(+) dermal macrophages secretes oncostatin m to maintain hair follicle stem cell quiescence and inhibit hair growth. Cell Stem Cell. 2019;24:654–669.e656. doi: 10.1016/j.stem.2019.01.011. - DOI - PubMed
    1. Peters EMJ, et al. Hair and stress: a pilot study of hair and cytokine balance alteration in healthy young women under major exam stress. PLoS ONE. 2017;12:e0175904. doi: 10.1371/journal.pone.0175904. - DOI - PMC - PubMed