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. 2021 Nov;25(22):10774-10777.
doi: 10.1111/jcmm.16962. Epub 2021 Oct 8.

Epithelial-Mesenchymal Transition in colorectal cancer: Annexin A2 is caught in the crosshairs

Murilo Ramos Rocha  1 , Jose Andres Morgado-Diaz  1
Affiliations

Epithelial-Mesenchymal Transition in colorectal cancer: Annexin A2 is caught in the crosshairs

Murilo Ramos Rocha et al. J Cell Mol Med. 2021 Nov.
No abstract available

Keywords: annexin A2; cofilin 1; colorectal cancer; epithelial-mesenchymal transition.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Overview of ANXA2 proposed pathway in EMT‐related processes. Through its phosphorylation after growth factor stimuli, ANXA2 can lead to LIMK phosphorylation and CFL1 inactivation. This pathway can cause the rearrangement of actin cytoskeleton and regulate endocytic pathways and the disassembly of cellular junctions. Phosphorylated ANXA2 may also provoke STAT3 phosphorylation, which will translocate to the nucleus and induce the EMT transcriptional program. These changes combined originate more motile cancer cells that will favour metastasis formation. ANXA2 control over c‐Myc mRNA translation also has an impact on EMT induction after growth factor stimuli
See this image and copyright information in PMC

References

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