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. 2022 Jan 5;225(1):5-9.
doi: 10.1093/infdis/jiab514.

Patterns of Antibody Response to Severe Acute Respiratory Syndrome Coronavirus 2 Among 1.6 Million Blood Donors: Impact of Vaccination, United States, December 2020-June 2021

Roger Y Dodd  1 , Edward P Notari  1 , Jaye P Brodsky  2 , Gregory A Foster  1 , Meng Xu  1 , Paula Saá  1 , Susan L Stramer  1
Affiliations

Patterns of Antibody Response to Severe Acute Respiratory Syndrome Coronavirus 2 Among 1.6 Million Blood Donors: Impact of Vaccination, United States, December 2020-June 2021

Roger Y Dodd et al. J Infect Dis. .

Abstract

From December 2020 to June 2021, 1654487 blood donors were tested for antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) S1 protein, and 1028547 (62.17%) were reactive. A rapid increase in prevalence was due to vaccination. Among a subset of 1567446 donors, 729771 (46.56%) reported SARS-CoV-2 vaccination, of whom 633769 (86.84%) were S1-antibody reactive only in response to vaccination and 68269 (9.35%) were reactive to both S1 and nucleocapsid in response to prior infection; the remainder were not reactive to either antibody. Among the 837675 (53.44%) donors who did not report vaccination, 210022 (25.07%) had reactivity to both antibodies and 29446 (3.52%) to S1 only.

Keywords: SARS-CoV-2; antibodies; blood donors; demographics; prevalence; vaccine.

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