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Meta-Analysis
. 2022 Jul;32(4):558-575.
doi: 10.1111/ipd.12934. Epub 2022 Feb 6.

Association between oral clefts and periodontal clinical measures: A meta-analysis

Tamer Marzouk  1   2 , Mostafa Youssef  1 , Alexandra Tsigarida  3 , Christy McKinney  4 , Cynthia Wong  2 , Lisa DeLucia  2 , Ritu Shah  2 , Hongyue Wang  5 , Hans Malmstrom  1 , Erin Shope  2   6
Affiliations
Meta-Analysis

Association between oral clefts and periodontal clinical measures: A meta-analysis

Tamer Marzouk et al. Int J Paediatr Dent. 2022 Jul.

Abstract

Aim: To conduct a systematic review and to evaluate the clinical parameters for periodontal diseases in individuals with cleft lip and/or palate (CL/P).

Design: The authors searched six indexed databases without any linguistic limitation through July 2021. The eligibility criteria were observational studies that compared the periodontal clinical measures of individuals with CL/P to those without CL/P. A meta-analysis was conducted using random-effects models with inverse variance weighting.

Results: The literature search generated 1277 records, and 40 full-text articles were reviewed. Twenty-three studies comprising 3235 individuals from four continents fulfilled our selection criteria. The meta-analysis revealed a significant difference in mean plaque index scores (MD = 0.31, 95% CI = 0.22, 0.41), gingival index scores (MD = 0.50, 95% CI = 0.24, 0.77), and periodontal pocket depth (MD = 0.64, 95% CI = 0.12, 1.16) between individuals with and without CL/P. A slight increase in clinical attachment loss was detected among individuals with CL/P; however, such an increase may have little clinical significance.

Conclusions: As age is positively related to periodontal disease progression, and individuals with CL/P are more likely to present with more plaque accumulation and gingival inflammation, clinicians should reinforce preventive dental care from an early age.

Keywords: cleft lip; cleft palate; gingival index; periodontal diseases; plaque index.

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References

REFERENCES

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