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. 2021 Nov-Dec;15(6):102302.
doi: 10.1016/j.dsx.2021.102302. Epub 2021 Sep 24.

High prevalence of post COVID-19 fatigue in patients with type 2 diabetes: A case-control study

Juhi Mittal  1 , Amerta Ghosh  2 , Surya Prakash Bhatt  3 , Shajith Anoop  4 , Irshad Ahmad Ansari  2 , Anoop Misra  5
Affiliations

High prevalence of post COVID-19 fatigue in patients with type 2 diabetes: A case-control study

Juhi Mittal et al. Diabetes Metab Syndr. 2021 Nov-Dec.

Abstract

Background: Post COVID-19 syndrome (PCS) has emerged as a major roadblock in the recovery of patients infected with SARS-CoV-2. Amongst many symptoms like myalgia, headache, cough, breathlessness; fatigue is is most prevalent and makes the patient severely debilitated. Research on PCS, in particular fatigue, in patients with diabetes has not been done.

Methodology: In this prospective study, we included patients with type 2 diabetes (T2D) who had COVID-19 (mild to moderate severity), and matched T2D patients who did not suffer from COVID-19. Demography, anthropometry, glycemic measures, treatment, and details of COVID-19 were recorded. Symptoms were scored using Chalder Fatigue Scale (reported as fatigue score, FS) and handgrip strength (in kg) was recorded by Jamar Hydraulic Hand Dynamometer.

Results: A total of 108 patients were included (cases, 52, controls, 56). Both groups were matched for age, duration of diabetes, BMI, TSH, serum albumin and vitamin D levels. T2D patients who had COVID-19 showed significantly more fatigue when compared with patients who did not have COVID-19 but both groups had comparable handgrip strength. Furthermore, patients with T2D with previous COVID-19 infection and who had FS > 4 have had significant higher inflammation markers during acute illness, and post COVID-19, had increased post prandial blood glucose levels, lost more weight, had reduced physical activity and showed significantly lower handgrip strength as compared to those with FS < 4.

Conclusion: Patients with T2D who had COVID-19 infection as compared to those without had significantly more fatigue after the acute illness, and those with higher FS had reduced handgrip strength indicating sarcopenia, even after careful matching for common contributory factors to fatigue at baseline. Rehabilitation of those with FS>4 after acute infection would require careful attention to nutrition, glycemic control and graduated physical activity protocol.

Keywords: COVID-19; Fatigue; Post COVID-19 syndrome; Sarcopenia; Type 2 diabetes.

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Conflict of interest statement

Declaration of competing interest Authors declare no conflict of interests.

References

    1. Raveendran A.V., Misra A. Post COVID-19 syndrome ("Long COVID") and diabetes: challenges in diagnosis and management. Diabetes Metab Syndr. 2021;15(5):102235. - PMC - PubMed
    1. COVID-19 rapid guideline: managing the long-term effects of COVID-19. National Institute for Health and Care Excellence: Clinical Guidelines. London2020. - PubMed
    1. Halpin S.J., McIvor C., Whyatt G., Adams A., Harvey O., McLean L., et al. Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: a cross-sectional evaluation. J Med Virol. 2021;93(2):1013–1022. - PubMed
    1. Augustin M., Schommers P., Stecher M., Dewald F., Gieselmann L., Gruell H., et al. Post-COVID syndrome in non-hospitalised patients with COVID-19: a longitudinal prospective cohort study. Lancet Reg Health Eur. 2021;6:100122. - PMC - PubMed
    1. Huang C., Huang L., Wang Y., Li X., Ren L., Gu X., et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet. 2021;397(10270):220–232. - PMC - PubMed