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Comparative Study
. 1986 Sep;83(17):6450-4.
doi: 10.1073/pnas.83.17.6450.

cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins

Comparative Study

cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins

D Z Fisher et al. Proc Natl Acad Sci U S A. 1986 Sep.

Abstract

The amino acid sequences deduced from cDNA clones of human lamin A and lamin C show identity between these two lamins except for an extra 9.0-kDa carboxyl-terminal tail that is present only in lamin A. Both lamins A and C contain an alpha-helical domain of approximately 360 residues that shows striking homology to a corresponding alpha-helical rod domain that is the structural hallmark of all intermediate filament proteins. However, the lamin alpha-helical domain is 14% larger than that of the intermediate filament proteins. In addition to the extensive homology to intermediate filament proteins as reported [McKeon, F., Kirschner, M. & Caput, D. (1986) Nature (London) 319, 463-468], a different 82-amino acid residue stretch at the carboxyl terminus of lamin A has been deduced and verified by amino acid sequencing. This region contains sequence homology to amino- and carboxylterminal domains of type I and type II epidermal keratins. Implications of the presence of these and other domains in lamins A and C for the assembly of the nuclear lamina are discussed.

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References

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