Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Sep;83(18):7059-63.
doi: 10.1073/pnas.83.18.7059.

Antitumor effects of L6, an IgG2a antibody that reacts with most human carcinomas

I Hellström, P L Beaumier, K E Hellström

Antitumor effects of L6, an IgG2a antibody that reacts with most human carcinomas

I Hellström et al. Proc Natl Acad Sci U S A. 1986 Sep.

Abstract

Mouse monoclonal antibody L6 (IgG2a subtype) recognizes a ganglioside antigen expressed at the surface of cells from human non-small-cell lung carcinomas, breast carcinomas, and colon carcinomas. We now show that this antibody can lyse L6 antigen-positive human tumor cells in the presence of Leu-11b-positive human lymphocytes (i.e., mediate antibody-dependent cellular cytotoxicity) or human serum (mediate complement-dependent cytotoxicity) and that it can inhibit the outgrowth of an L6 antigen-positive human tumor transplanted onto nude mice.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Immunol. 1983 Jul;131(1):180-5 - PubMed
    1. Proc Natl Acad Sci U S A. 1984 Jan;81(1):216-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 Feb;82(4):1242-6 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 Mar;82(5):1499-502 - PubMed
    1. J Nucl Med. 1986 Jun;27(6):824-8 - PubMed

Publication types

LinkOut - more resources