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. 2022 Feb;38(2):124-127.
doi: 10.1016/j.tig.2021.09.009. Epub 2021 Oct 7.

Histone lactylation: epigenetic mark of glycolytic switch

Xiaofeng Dai  1 , Xinyu Lv  2 , Erik W Thompson  3 , Kostya Ken Ostrikov  4
Affiliations

Histone lactylation: epigenetic mark of glycolytic switch

Xiaofeng Dai et al. Trends Genet. 2022 Feb.

Abstract

Histone lactylation and acetylation compete for epigenetic modification of lysines and mark the levels of lactates and acetyl-CoA. Whether pyruvate is committed to lactate or acetyl-CoA generation as the outlet of glycolysis determines cell fate towards malignancy or not. Taking control over the glycolytic switch as marked by lactylation suggests novel therapeutic opportunities against cancers.

Keywords: acetylation; epigenetic mark; glycolysis switch; lactylation.

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Conflict of interest statement

Declaration of interests The authors declare no interests.

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