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Review
. 2021 Dec;8(4):1535-1549.
doi: 10.1007/s40744-021-00382-0. Epub 2021 Oct 9.

Esophageal Dysfunction in Systemic Sclerosis: An Update

Bo Li  1   2 , Junqing Yan  3 , Jincheng Pu  2 , Jianping Tang  2 , Shuchang Xu  4 , Xuan Wang  5
Affiliations
Review

Esophageal Dysfunction in Systemic Sclerosis: An Update

Bo Li et al. Rheumatol Ther. 2021 Dec.

Abstract

Esophageal motility disorders are prevalent in 90% of patients with systemic sclerosis [scleroderma (SSc)], with an increased mortality rate in patients with severe esophageal involvement. Esophageal smooth muscle damage caused by ischemia, nerve damage, and inflammatory factors may be responsible for discomfort and various complications in these patients. The clinical manifestations are diverse. Most hospitals still use traditional esophageal manometry and 24-h pH monitoring to diagnose esophageal function in patients with SSc. The aim of this review article is to provide an overview of SSc-related esophageal motility disorders and related research progress, including the pathogenesis and clinical features of these disorders and the progress made in endoscopic diagnosis. We also discuss the possible pathogenesis and potential therapeutic targets.

Keywords: Clinical features; Complications; Esophageal motility disorders/physiopathology; Esophageal motility disorders/therapy; Systemic scleroderma.

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Figures

Fig. 1
Fig. 1
Possible mechanism of esophageal lesions in patients with systemic sclerosis
Fig. 2
Fig. 2
Simulation diagram of the structure of esophageal lesions in patients with systemic sclerosis
See this image and copyright information in PMC

References

    1. Emmanuel AJ. Current management of the gastrointestinal complications of systemic sclerosis. Nat Rev Gastroenterol Hepatol. 2016;13(8):461–472. - PubMed
    1. Ebert EC. Esophageal disease in progressive systemic sclerosis. Curr Treat Options Gastroenterol. 2008;11(1):64–69. - PubMed
    1. Alastal Y, Hammad TA, Renno A, et al. Gastrointestinal manifestations associated with systemic sclerosis: results from the nationwide inpatient sample. Ann Gastroenterol. 2017;30(5):498. - PMC - PubMed
    1. Aggarwal N, Lopez R, Gabbard S, Wadhwa N, Devaki P, Thota PN. Spectrum of esophageal dysmotility in systemic sclerosis on high-resolution esophageal manometry as defined by Chicago classification. Dis Esophagus. 2017;30(12):1–6. - PubMed
    1. Vischio J, Saeed F, Karimeddini M, et al. Progression of esophageal dysmotility in systemic sclerosis. J Rheumatol. 2012;39(5):986–991. - PubMed

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