Commentary: Rapalink-1 Increased Infarct Size in Early Cerebral Ischemia-Reperfusion With Increased Blood-Brain Barrier Disruption
- PMID: 34630168
- PMCID: PMC8493210
- DOI: 10.3389/fphys.2021.761556
Commentary: Rapalink-1 Increased Infarct Size in Early Cerebral Ischemia-Reperfusion With Increased Blood-Brain Barrier Disruption
Keywords: Rapalink-1; mTOR–mammalian target of rapamycin; neuroprotection; rapamycin; stroke.
Conflict of interest statement
AB is a co-founder of Brainomix, a company that develops electronic ASPECTS (e-ASPECTS), an automated method to evaluate ASPECTS in stroke patients. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Comment on
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Rapalink-1 Increased Infarct Size in Early Cerebral Ischemia-Reperfusion With Increased Blood-Brain Barrier Disruption.Front Physiol. 2021 Jul 20;12:706528. doi: 10.3389/fphys.2021.706528. eCollection 2021. Front Physiol. 2021. PMID: 34354602 Free PMC article.
References
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- Buckley K. M., Hess D. L., Sazonova I. Y., Periyasamy-Thandavan S., Barrett J. R., Kirks R., et al. . (2014). Rapamycin up-regulation of autophagy reduces infarct size and improves outcomes in both permanent MCAL, and embolic MCAO, murine models of stroke. Exp. Transl. Stroke Med. 6:8. 10.1186/2040-7378-6-8 - DOI - PMC - PubMed
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