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Review
. 2021 Sep 27;12(5):57-69.
doi: 10.4331/wjbc.v12.i5.57.

Proteomics: Concepts and applications in human medicine

Safa Al-Amrani  1 , Zaaima Al-Jabri  1 , Adhari Al-Zaabi  2 , Jalila Alshekaili  3 , Murtadha Al-Khabori  4
Affiliations
Review

Proteomics: Concepts and applications in human medicine

Safa Al-Amrani et al. World J Biol Chem. .

Abstract

Proteomics is the complete evaluation of the function and structure of proteins to understand an organism's nature. Mass spectrometry is an essential tool that is used for profiling proteins in the cell. However, biomarker discovery remains the major challenge of proteomics because of their complexity and dynamicity. Therefore, combining the proteomics approach with genomics and bioinformatics will provide an understanding of the information of biological systems and their disease alteration. However, most studies have investigated a small part of the proteins in the blood. This review highlights the types of proteomics, the available proteomic techniques, and their applications in different research fields.

Keywords: Biomarker; Drug discovery; Mass spectrometry; Proteomics; Two-dimensional electrophoresis.

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Conflict of interest statement

Conflict-of-interest statement: All authors declare no conflict of interest.

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