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Review
. 2021 Sep 1;11(4):e2021099.
doi: 10.5826/dpc.1104a99. eCollection 2021 Sep.

Recurrent Aphthous Stomatitis: Treatment and Management

Marco Manfredini  1 , Stefania Guida  1 , Matteo Giovani  1 , Nicola Lippolis  1 , Enrico Spinas  2 , Francesca Farnetani  1 , Annunziata Dattola  3 , Eleonora Di Matteo  3 , Giovanni Pellacani  4 , Luca Giannetti  5
Affiliations
Review

Recurrent Aphthous Stomatitis: Treatment and Management

Marco Manfredini et al. Dermatol Pract Concept. .

Abstract

Background: Recurrent aphthous stomatitis consists of the presence of abrasions or ulcerations located on mucosae (oral or genital).

Objectives: The aim of this article is to review the current literature providing the main causes related to recurrent aphthous stomatitis and insights into treatment and management of this clinical condition.

Methods: Articles matching terms that correlated with "recurrent aphthous stomatitis" were searched on PubMed, EMBASE, and Cochrane Library and selected according to their pertinence.

Results: Several forms of aphthous stomatitis have been described, based on the extent (minor, major), morphology (herpetiform) and associations to other signs (Behçet syndrome or more complex inflammatory syndromes). Topical as well as systemic treatments have been described to obtain a faster remission of the aphthosis or to reduce associated symptoms such as pain.

Conclusions: Recurrent aphthous stomatitis can have a mild-to-severe clinical appearance, being mainly localized on the oral mucosa or at the level of the genital area. Different strategies have been described so far for its management and treatment.

Keywords: Behçet disease; aphthae; aphthosis; autoimmune; herpetiform; oral; recurrent; treatment.

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Conflict of interest statement

Competing interests: The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Recurrent aphthous stomatitis in a patient with Adamantiades-Behçet disease.
See this image and copyright information in PMC

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