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. 2021;40(4):196-203.
doi: 10.12938/bmfh.2021-018. Epub 2021 Aug 10.

Effects of the intake of non-live Bifidobacterium bifidum on the faecal IgA of full-term infants: a double-blind, randomised, placebo-controlled study

Masaki Terahara  1 , Yoshitaka Nakamura  2 , Misato Tsuboi  2 , Shinji Jinno  2 , Takamitsu Tsukahara  3 , Takao Miyake  4 , Naoki Shimojo  5
Affiliations

Effects of the intake of non-live Bifidobacterium bifidum on the faecal IgA of full-term infants: a double-blind, randomised, placebo-controlled study

Masaki Terahara et al. Biosci Microbiota Food Health. 2021.

Abstract

Bifidobacterium bifidum OLB6378 (OLB6378) was selected as a strain that enhances the production of secretory immunoglobulin A (IgA) in vitro. This ability of non-live OLB6378 has been shown by a clinical trial in preterm infants. In the present study, we examined whether non-live OLB6378 also enhances the production of secretory IgA, even in full-term infants. One hundred full-term infants were allocated to receive formula with (BbF group, 49 infants) or without non-live OLB6378 (PF group, 51 infants). Breastfeeding was prioritised, so infant formula was used for infants with breastfeeding difficulties. The intervention was initiated by five days of age. The faecal IgA concentration and OLB6378 level were determined at one, two, four, and eight weeks of age. Faecal IgA in the BbF group (1.04 ± 0.47 mg/g of faeces, n=45) was significantly higher than that in the PF group (0.85 ± 0.42 mg/g of faeces, n=49) at four weeks of age (p=0.047). OLB6378 was not detected in faeces at any age. This indicated that production of secretory IgA in full-term infants may also be enhanced by non-live OLB6378 intake.

Keywords: breastfeeding; infant formula; newborn; probiotics.

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Figures

Fig. 1.
Fig. 1.
Study flowchart. PF: placebo infant formula; BbF: infant formula containing non-live B. bifidum OLB6378; FAS: Full Analysis Set.
Fig. 2.
Fig. 2.
Transition of faecal IgA. PF: placebo infant formula; BbF: infant formula containing non-live B. bifidum OLB6378; E: exclusive breastfeeding; NS: not significant (both Student’s t-test and Brunner–Munzel test); ap<0.05 (t-test); bp<0.05 (Brunner–Munzel test).
Fig. 3.
Fig. 3.
Relationship between formula intake and faecal IgA. The Spearman’s rank correlation coefficients (p-value) at one, two, four, and eight weeks of age were –0.28 (<0.01), –0.38 (<0.01), –0.13 (0.22), and –0.08 (0.49), respectively.
Fig. 4.
Fig. 4.
Subgroup analyses of faecal IgA. Different letters indicate significant differences at each age (Tukey test).
See this image and copyright information in PMC

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References

    1. Yasui H, Nagaoka N, Mike A, Hayakawa K, Ohwaki M. 1992. Detection of Bifidobacterium strains that induce large quantities of IgA. Microb Ecol Health Dis 5: 155–162.
    1. Makioka Y, Tsukahara T, Ijichi T, Inoue R. 2018. Oral supplementation of Bifidobacterium longum strain BR-108 alters cecal microbiota by stimulating gut immune system in mice irrespectively of viability. Biosci Biotechnol Biochem 82: 1180–1187. - PubMed
    1. Terahara M. 2017. Challenge of development of probiotics for neonates. Milk Science 66: 247–253 (in Japanese).
    1. Tanaka K, Tsukahara T, Yanagi T, Nakahara S, Furukawa O, Tsutsui H, Koshida S. 2017. Bifidobacterium bifidum OLB6378 simultaneously enhances systemic and mucosal humoral immunity in low birth weight infants: a non-randomized study. Nutrients 9: 195. - PMC - PubMed
    1. Ahmad I, Nemet D, Eliakim A, Koeppel R, Grochow D, Coussens M, Gallitto S, Rich J, Pontello A, Leu SY, Cooper DM, Waffarn F. 2010. Body composition and its components in preterm and term newborns: a cross-sectional, multimodal investigation. Am J Hum Biol 22: 69–75. - PMC - PubMed