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Review
. 2021 Sep 23:9:746714.
doi: 10.3389/fcell.2021.746714. eCollection 2021.

Long Non-coding RNA Small Nucleolar RNA Host Gene 14, a Promising Biomarker and Therapeutic Target in Malignancy

Shen Shen  1   2 , Yanfang Wang  3 , Yize Zhang  1   2 , Zihui Dong  1   2 , Jiyuan Xing  1   2
Affiliations
Review

Long Non-coding RNA Small Nucleolar RNA Host Gene 14, a Promising Biomarker and Therapeutic Target in Malignancy

Shen Shen et al. Front Cell Dev Biol. .

Abstract

Small nucleolar RNA host gene 14 (SNHG14) is a long non-coding RNA found to be overexpressed in various types of cancers. Moreover, the expression level of SNHG14 was closely associated with multiple clinicopathological characteristics such as prognosis, tumor differentiation, TNM stage, and lymph node metastasis. Functionally, gain- and loss-of-function of SNHG14 revealed that overexpressed SNHG14 promoted cancer cell viability, invasion, and migration, whereas its down-regulation produced the opposite effect. Mechanistically, regulating its target gene expression by sponging distinct miRNAs might be the major mechanism underlying the oncogenic functions of SNHG14. Thus, SNHG14 might be a promising prognostic biomarker and therapeutic target for cancers. In this review, we discuss the expression profile, biological function, and molecular mechanisms of SNHG14 in cancers to provide a molecular basis for the clinical utility of SNHG14 in the future.

Keywords: SNHG14; biomarker; lncRNA; malignancy; prognosis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
SNHG14 enhances non-small cell lung cancer cell proliferation, invasion, and migration and inhibits cell apoptosis by regulating target genes through sponging miRNAs.
FIGURE 2
FIGURE 2
SNHG14 mediates mechanisms involved in HCC.
FIGURE 3
FIGURE 3
Function and molecular mechanism of SNHG14 in pancreatic cancer.
See this image and copyright information in PMC

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