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Review
. 2021 Sep;32(3):422-434.
doi: 10.1007/s13337-021-00728-w. Epub 2021 Jul 28.

In-depth summary over cytomegalovirus infection in allogeneic hematopoietic stem cell transplantation recipients

Samira Karami  1 , Elham Roshandel  1 , Haniyeh Ghaffari Nazari  1 , Abbas Hajifathali  1 , Farzaneh Tavakoli  1 , Sayeh Parkhideh  1
Affiliations
Review

In-depth summary over cytomegalovirus infection in allogeneic hematopoietic stem cell transplantation recipients

Samira Karami et al. Virusdisease. 2021 Sep.

Abstract

In this study, we reviewed various aspects of cytomegalovirus infection, including pathophysiology, diagnosis methods, and antiviral treatments. Background: Infections continue to be a major reason of complications like high non-relapse morbidity and mortality rate after allogenic hematopoietic stem cell transplantation. Cytomegalovirus is the most common infection in immunocompromised patients or those with graft-versus-host disease. The Latent-cytomegalovirus disease could increase the risk of reactivation in allogenic hematopoietic stem cell transplantation patients and lead to profound adverse effects on transplantation outcomes. Cytomegalovirus-specific CD4 + and CD8 + T cells reconstitution is crucial for protection against the virus reactivation. Different prophylactic, pre-emptive, and therapeutic anti-viral drugs are available to prevent cytomegalovirus infection/reactivation and treat resistant infections. Conclusion: Although there has been introduced various CMV antiviral treatment strategies like antiviral drugs, Vaccination, passive immunotherapies and adoptive transfer of CMV-specific T cells, further clinical trials are required to approve current therapies.

Keywords: Allogeneic; Cytomegalovirus; Hematopoietic stem cell transplantation; Infection.

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Conflict of interest statement

Conflict of InterestThe authors declare no conflict of interest.

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