Global approaches for profiling transcription initiation
- PMID: 34632443
- PMCID: PMC8496859
- DOI: 10.1016/j.crmeth.2021.100081
Global approaches for profiling transcription initiation
Abstract
Transcription start site (TSS) selection influences transcript stability and translation as well as protein sequence. Alternative TSS usage is pervasive in organismal development, is a major contributor to transcript isoform diversity in humans, and is frequently observed in human diseases including cancer. In this review, we discuss the breadth of techniques that have been used to globally profile TSSs and the resulting insights into gene regulation, as well as future prospects in this area of inquiry.
Conflict of interest statement
DECLARATION OF INTERESTS R.A.P. and G.E.Z. are employees of eGenesis, Inc. The topics covered in this review are not related to any current work at the company.
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