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. 2022 Apr;13(4):234-238.
doi: 10.1007/s13238-021-00880-5. Epub 2021 Oct 11.

New concepts for generating interspecies chimeras using human pluripotent stem cells

Alejandro De Los Angeles  1 , Jun Wu  2   3
Affiliations

New concepts for generating interspecies chimeras using human pluripotent stem cells

Alejandro De Los Angeles et al. Protein Cell. 2022 Apr.
No abstract available

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Figures

Figure 1
Figure 1
Strategies to improve interspecies chimerism. (A) Blastocyst chimera potential of human naïve, intermediate and primed PS cells. (B) Inhibition of cell competition via genetic perturbation of MYD88, P65 (also known as RELA), or TP53 promotes the survival and chimerism of human primed PS cells in mouse embryos. (C) Igf1r-null mouse embryos provide a “cell competitive” niche in multiple organs from mid-gestation for donor rat or mouse naïve PS cells to thrive. Created with BioRender.com
See this image and copyright information in PMC

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