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. 2021 Dec;174(12):1768-1770.
doi: 10.7326/M21-2483. Epub 2021 Oct 12.

Antibody Responses After SARS-CoV-2 mRNA Vaccination in Adults With Inflammatory Bowel Disease

Affiliations

Antibody Responses After SARS-CoV-2 mRNA Vaccination in Adults With Inflammatory Bowel Disease

Gil Y Melmed et al. Ann Intern Med. 2021 Dec.

Erratum in

No abstract available

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Conflict of interest statement

Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M21-2483.

Figures

Figure.
Figure.. Week 8 anti-spike IgG (log10) levels, by medication class.
The dotted line represents the threshold for a positive antibody result (50 AU/mL [Abbott Labs]). IL = interleukin; JAK = Janus kinase; TNF = tumor necrosis factor-α.

References

    1. Wallace BI , Kenney B , Malani PN , et al. Prevalence of immunosuppressive drug use among commercially insured US adults, 2018-2019. JAMA Netw Open. 2021;4:e214920. [PMID: ] doi:10.1001/jamanetworkopen.2021.4920 - DOI - PMC - PubMed
    1. Boyarsky BJ , Werbel WA , Avery RK , et al. Antibody response to 2-dose SARS-CoV-2 mRNA vaccine series in solid organ transplant recipients. JAMA. 2021;325:2204-2206. [PMID: ] doi:10.1001/jama.2021.7489 - DOI - PMC - PubMed
    1. Kennedy NA , Lin S , Goodhand JR , et al; Contributors to the CLARITY IBD study. Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD. Gut. 2021;70:1884-1893. [PMID: ] doi:10.1136/gutjnl-2021-324789 - DOI - PubMed
    1. Wong SY , Dixon R , Martinez Pazos V , et al; ICARUS-IBD Working Group. Serologic response to messenger RNA coronavirus disease 2019 vaccines in inflammatory bowel disease patients receiving biologic therapies. Gastroenterology. 2021;161:715-718.e4. [PMID: ] doi:10.1053/j.gastro.2021.04.025 - DOI - PMC - PubMed
    1. Kappelman MD , Weaver KN , Boccieri M , et al; PREVENT-COVID Study Group. Humoral immune response to messenger RNA COVID-19 vaccines among patients with inflammatory bowel disease. Gastroenterology. 2021;161:1340-1343.e2. [PMID: ] doi:10.1053/j.gastro.2021.06.016 - DOI - PMC - PubMed