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Review
. 2021 Nov;47(4):643-653.
doi: 10.1016/j.rdc.2021.07.012. Epub 2021 Sep 2.

Pharmacosurveillance in Juvenile Idiopathic Arthritis

Natalie J Shiff  1 , Timothy Beukelman  2
Affiliations
Review

Pharmacosurveillance in Juvenile Idiopathic Arthritis

Natalie J Shiff et al. Rheum Dis Clin North Am. 2021 Nov.

Abstract

The advent of biologic disease-modifying antirheumatic drugs targeting specific cytokines or cell-cell interactions has dramatically changed the outlook of patients with juvenile idiopathic arthritis. However, safety concerns remain around the use of therapeutic agents for children with juvenile idiopathic arthritis. Foremost among these are the risks of serious infections and malignancy. This article provides an overview of methodologies for pharmacosurveillance in juvenile idiopathic arthritis, including spontaneous reporting systems and the use of diverse data sources, such as electronic health records, administrative claims, and clinical registries. The risks of infections and malignancies are then briefly reviewed.

Keywords: Biologics; JIA; Pediatric rheumatology; Pharmacosurveillance.

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Conflict of interest statement

Disclosure N.J. Shiff is a stockowner of AbbVie, Gilead, Pfizer, Novartis, and Sanofi; and has previously received salary support from CARRA. T. Beukelman receives salary support from CARRA; and has received consulting fees from Novartis and UCB.

MeSH terms