Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Nov;6(11):1345-1346.
doi: 10.1038/s41564-021-00982-0.

Malaria vaccine roller coaster

Affiliations
Comment

Malaria vaccine roller coaster

Irene N Nkumama et al. Nat Microbiol. 2021 Nov.

Abstract

A promising vaccine fails to provide durable protection against infection and clinical malaria in infants, a key malaria vaccine target population, in a phase 2b clinical trial. The need for a highly effective vaccine against malaria remains as urgent as ever.

PubMed Disclaimer

Conflict of interest statement

Competing interests

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. The highs and lows of PfSPZ malaria vaccine development.
A flow chart of notable exciting and disappointing moments in the course of developing the PfSPZ vaccine. DVI, direct intravenous injection; IM, intramuscular; SC, subcutaneous.

Comment on

References

    1. Oneko M, et al. Nat Med. 2021 doi: 10.1038/s41591-021-01470-y. - DOI
    1. Luke TC, Hoffman SL. J Exp Biol. 2003;206:3803–3808. - PubMed
    1. Epstein JE, et al. Science. 2011;334:475–480. - PubMed
    1. Seder RA, et al. Science. 2013;341:1359–1365. - PubMed
    1. Sissoko MS, et al. Lancet Infect Dis. 2017;17:498–509. - PMC - PubMed

MeSH terms

Substances