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Comment
. 2021 Oct;27(10):1687-1688.
doi: 10.1038/s41591-021-01524-1. Epub 2021 Oct 11.

Caution at psychiatry's psychedelic frontier

Matthew J Burke  1   2   3   4 , Daniel M Blumberger  5   6
Affiliations
Comment

Caution at psychiatry's psychedelic frontier

Matthew J Burke et al. Nat Med. 2021 Oct.
No abstract available

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  • MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study.
    Mitchell JM, Bogenschutz M, Lilienstein A, Harrison C, Kleiman S, Parker-Guilbert K, Ot'alora G M, Garas W, Paleos C, Gorman I, Nicholas C, Mithoefer M, Carlin S, Poulter B, Mithoefer A, Quevedo S, Wells G, Klaire SS, van der Kolk B, Tzarfaty K, Amiaz R, Worthy R, Shannon S, Woolley JD, Marta C, Gelfand Y, Hapke E, Amar S, Wallach Y, Brown R, Hamilton S, Wang JB, Coker A, Matthews R, de Boer A, Yazar-Klosinski B, Emerson A, Doblin R. Mitchell JM, et al. Nat Med. 2021 Jun;27(6):1025-1033. doi: 10.1038/s41591-021-01336-3. Epub 2021 May 10. Nat Med. 2021. PMID: 33972795 Free PMC article. Clinical Trial.

References

    1. Mitchell, J. M. et al. MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study. Nat. Med. https://doi.org/10.1038/s41591-021-01336-3 (2021).
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    1. Ashar, Y. K., Chang, L. J. & Wager, T. D. Brain mechanisms of the placebo effect: an affective appraisal account. Annu Rev. Clin. Psychol. 13, 73–98 (2017). - DOI
    1. Burke, M. J., Kaptchuk, T. J. & Pascual-Leone, A. Challenges of differential placebo effects in contemporary medicine: the example of brain stimulation. Ann. Neurol. 85, 12–20 (2019). - DOI
    1. Feder, A. et al. Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial. JAMA Psychiatry 71, 681–688 (2014). - DOI

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