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. 2022 Feb;196(3):559-565.
doi: 10.1111/bjh.17890. Epub 2021 Oct 11.

COVID-19 infection in chronic myeloid leukaemia after one year of the pandemic in Italy. A Campus CML report

Massimo Breccia  1 , Elisabetta Abruzzese  2 , Vincenzo Accurso  3 , Immacolata Attolico  4 , Sara Barulli  5 , Micaela Bergamaschi  6 , Gianni Binotto  7 , Monica Bocchia  8 , Massimiliano Bonifacio  9 , Giovanni Caocci  10 , Isabella Capodanno  11 , Fausto Castagnetti  12 , Francesco Cavazzini  13 , Elena Crisà  14 , Monica Crugnola  15 , Maria Stella De Candia  16 , Chiara Elena  17 , Carmen Fava  18 , Sara Galimberti  19 , Antonella Gozzini  20 , Gabriele Gugliotta  12 , Tamara Intermesoli  21 , Alessandra Iurlo  22 , Gaetano La Barba  23 , Roberto Latagliata  24 , Sabrina Leonetti Crescenzi  25 , Luciano Levato  26 , Giuseppina Loglisci  27 , Alessandro Lucchesi  28 , Luigiana Luciano  29 , Francesca Lunghi  30 , Debora Luzi  31 , Alessandra Malato  32 , Maria Cristina Miggiano  33 , Michele Pizzuti  34 , Patrizia Pregno  35 , Davide Rapezzi  36 , Giovanna Rege-Cambrin  37 , Gianantonio Rosti  28 , Sabina Russo  38 , Rosaria Sancetta  39 , Anna Rita Scortechini  40 , Federica Sorà  41 , Paolo Sportoletti  42 , Fabio Stagno  43 , Agostino Tafuri  44 , Mario Tiribelli  45 , Robin Foà  1 , Giuseppe Saglio  46
Affiliations

COVID-19 infection in chronic myeloid leukaemia after one year of the pandemic in Italy. A Campus CML report

Massimo Breccia et al. Br J Haematol. 2022 Feb.

Abstract

Limited information is available on the impact of the COVID-19 pandemic on the management of chronic myeloid leukaemia (CML). The Campus CML network collected retrospective information on 8 665 CML patients followed at 46 centres throughout Italy during the pandemic between February 2020 and January 2021. Within this cohort, we recorded 217 SARS-CoV-2-positive patients (2·5%). Most patients (57%) were diagnosed as having SARS-CoV-2 infection during the second peak of the pandemic (September 2020 to January 2021). The majority (35%) was aged between 50 and 65 years with a male prevalence (73%). Fifty-six percent of patients presented concomitant comorbidities. The median time from CML diagnosis to SARS-CoV-2 infection was six years (three months to 18 years). Twenty-one patients (9·6%) required hospitalization without the need of respiratory assistance, 18 (8·2%) were hospitalized for respiratory assistance, 8 (3·6%) were admitted to an intensive care unit, while 170 (78%) were only quarantined. Twenty-three percent of patients discontinued tyrosine kinase inhibitor (TKI) therapy during the infection. Twelve patients died due to COVID-19 with a mortality rate of 5·5% in the positive cohort and of 0·13% in the whole cohort. We could also document sequelae caused by the SARS-CoV-2 infection and an impact of the pandemic on the overall management of CML patients.

Keywords: Covid-19; chronic myeloid leukemia; mortality; prognosis.

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Figures

Fig 1
Fig 1
Covid‐19 incidence according to the phase of the pandemic. [Colour figure can be viewed at wileyonlinelibrary.com]
Fig 2
Fig 2
Presenting symptoms at the time of COVID‐19 diagnosis. [Colour figure can be viewed at wileyonlinelibrary.com]
See this image and copyright information in PMC

Comment in

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