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Review
. 2022 Jan 1;34(1):89-94.
doi: 10.1097/CCO.0000000000000800.

Novel immunotherapeutic drugs for the treatment of lung cancer

Affiliations
Review

Novel immunotherapeutic drugs for the treatment of lung cancer

Ling Peng et al. Curr Opin Oncol. .

Abstract

Purpose of review: Cancer cells evade immune surveillance partly due to the immunosuppressive features of the tumor microenvironment (TME). Currently approved immuno-oncology drugs for the treatment of lung cancer are aimed to inhibit immune checkpoints, such as programmed death protein-1 (PD-1), PD ligand-1 (PD-L1) and cytotoxic T lymphocyte-associated antigen 4. Despite these, researchers are currently racing to create the optimal cancer immunotherapy treatments.

Recent findings: Novel immunotherapeutic drugs mainly act on activated immune cells and exert their therapeutic effects by enhancing antitumor responses. In this article, we review new therapies for the treatment of lung cancer that enhance T cell priming, remove coinhibitory signals, supply costimulatory signals and condition the TME.

Summary: As more immunotherapeutic targets are in studies, designing multimodal strategies to provide greater efficacy with lower toxicity will be necessary.

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References

    1. Yao S, Zhu Y, Chen L. Advances in targeting cell surface signalling molecules for immune modulation. Nat Rev Drug Discov 2013; 12:130–146.
    1. Whiteside TL, Demaria S, Rodriguez-Ruiz ME, et al. Emerging opportunities and challenges in cancer immunotherapy. Clin Cancer Res 2016; 22:1845–1855.
    1. Goldberg MV, Drake CG. LAG-3 in cancer immunotherapy. Curr Top Microbiol Immunol 2011; 344:269–278.
    1. Anderson AC, Joller N, Kuchroo VK. Lag-3, Tim-3, and TIGIT: Co-inhibitory receptors with specialized functions in immune regulation. Immunity 2016; 44:989–1004.
    1. Yu X, Huang X, Chen X, et al. Characterization of a novel antihuman lymphocyte activation gene 3 (LAG-3) antibody for cancer immunotherapy. MAbs 2019; 11:1139–1148.